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Inventi Impact: Med Chem

Articles

  • Inventi:pmc/31398/20
    Synthesis and Cytotoxic Activity of New Thiazolopyrimidine Sugar Hydrazones and Their\nDerived Acyclic Nucleoside Analogues
    Research 2020 : April - June
    Ebtesam A Basiony, Allam A Hassan, Zahra M Al-Amshany, Ahmed A Abd-Rabou, Adel A-H Abdel-Rahman, Nasser A Hassan, Wael A El-Sayed

    New thienyl- or chlorophenyl-substituted thiazolopyrimidine derivatives and their derived\nsugar hydrazones incorporating acyclic d-galactosyl or d-xylosyl sugar moieties in addition to their\nper-O-acetylated derivatives were synthesized. Heterocyclization of the formed sugar hydrazones\nafforded the derived acyclic nucleoside analogues possessing the 1,3,4-oxadiazoline as modified\nnucleobase via acetylation followed by the cyclization process. The cytotoxic activity of the synthesized\ncompounds was studied against human breast cancer MCF7 and MDA-MB-231 cell lines as well as\nhuman colorectal cancer HCT 116 and Caco-2 cell lines. High activities were revealed by compounds\n1, 8, 10, 11, and 13 against Caco-2 and MCF7 cells in addition to moderate activities exhibited by other\ncompounds against HCT116 or MDA-MB-231 cells������

    How to Cite this Article
    Attribution/ CC Compliant Citation: Basiony, Ebtesam A., et al. \"Synthesis and Cytotoxic Activity of New\nThiazolopyrimidine Sugar Hydrazones and Their Derived Acyclic Nucleoside Analogues.\" Molecules 25.2 (2020): 399.\nhttps://doi:10.3390/molecules25020399\nhttp://creativecommons.org/licenses/by/4.0/\n\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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